I've noticed profound benefits. C60 Evo cured my lifelong heartburn. My stomach went from egg shell, to cast iron. My basic metabolic panel blood tests, which my doctor does twice a year to monitor my high blood pressure, improved dramatically. Everything went from borderline, or worse, to perfect. My doctor flipped his wig. I also notice most of the more subjective benefits that everyone mentions like better sleep, a calming of the mind, better concentration, and less fatigue. I'll be 68 this year and I've been taking c60 for 3 1/2 years. I've tried several c60 products, and C60 EVO Olive oil is my favorite.